Dr. Massey and Sister Jo race to Galilee to try to stop the impending birth of the anti-Christ and to find Hawk.
In Prague, Massey and Sister Jo find a strange box containing a puzzle that may offer clues about the birth of the anti-Christ; Haden's followers attack the Sisters of Mercy Convent and comatose Olivia as Haden attempts to escape from prison.
The kidnappers present Massey's stepson with a horrible choice; Haden's trial begins, but his charisma and rhetoric gain him respect from his fellow prisoners; the Sisters of Mercy ask for help, fearing their convent has been infiltrated.
Dr. Massey and Sister Jo travel to Rome to speak with the miracle child's mother, who believes that shadowy figures tried to wrest the baby from her; Massey's stepson (Mark Rendall) is lured away from his bodyguards and into the Satanists' grasp.
With Satanist Isaiah Haden in prison, Dr. Massey tries to return to his old life, then he must investigate the origin of the so-called miracle child, the sole survivor of a shipwreck off Patmos, Greece.
While Dr. Massey is still recovering from the loss of his daughter to a maniacal murderer, he embarks on a journey through the unfamiliar world of faith with the guidance of Sister Josepha Montafiore.