Dr. Jackie Collette is visited by a college friend who had survived cancer, but learns it has returned during a routine checkup.
Letty discovers Dr. Terry Howland (Christine Baranski) is an alcoholic and may be performing surgery while intoxicated.
Dr. Lanning tries to perform an unorthodox procedure to help a woman become pregnant by her HIV-infected husband.
Dr. Keating believes a gay teenager's injury is the result of a suicide attempt; a patient grows weary of waiting for a lung donor.
Dr. Brennan deals with tough emotions as her marriage deteriorates and she treats a girl who has leukemia.
The hospital is flooded with patients delivering premature babies; an inexperienced resident oversees her first delivery.
A tough surgeon (Christine Baranski) fights with Dr. Kokoris over a patient and tries to have him fired.
Jumping to conclusions, Dr. Keating calls child abuse authorities after discovering bruises on a boy's back.
Drs. Kokoris and Slingerland spar over whether to amputate the leg of a diabetic patient (guest star Red Buttons); Dr. Collette performs a facelift on an aging actor (guest star Corbin Bernsen).
Dr. Brennan's young patient doesn't know the truth about his medical condition; Dr. Keating finds a sperm donor.
Drs. Slingerland and Jordan diagnose a serious heart condition in a cable-car worker; Dr. Keating begins reviewing sperm donors.
A pregnant patient's teenage daughter tells Keating that she wants to get her tubes tied; a man's only hope for a liver match is his imprisoned brother.
A firefighter (Dylan Walsh) implores Dr. Collette to treat his best friend, in spite of her aversion to burn cases; hoping to repair her marriage, Dr. Brennan asks Dr. Kokoris to leave Presidio Med and return to Greece.
Doctors working at a San Francisco hospital practice medicine and try to cure their personal problems. In this episode: Drs. Lanning and Keating team up to save a newborn baby.