Dr. Finn, her two sons, and Isaac get lost in space; Ed and the crew set out to save them.
Ed sends a team to find missing anthropologists on a planet similar to 21st-century Earth; the mission goes awry when they realize the planet uses a public voting system to determine punishment.
Ed and Gordon are sent on a dangerous undercover mission to infiltrate a Krill ship and obtain a copy of the Krill bible.
The crew saves a stranded ship and its attractive Capt. Pria; Ed becomes smitten with Pria, but Kelly is suspicious; Gordon attempts to teach Isaac the art of pulling off a practical joke.
Ed and the crew encounter a massive vessel adrift in space and in danger of colliding with a star; Bortus, Gordon, and John fend off a Krill attack on another Union ship.
The Orville travels to Bortus' planet; the crew debates controversial surgeries for newborns.
Ed and Kelly find themselves prisoners in a replica of their former home; Alara must take first command of the Orville to attempt a heroic rescue; Bortus and Klyden receive unexpected news.
Ed Mercer's enthusiasm about his promotion to captain dampens when his ex-wife, Kelly, gets assigned to be his first officer; an alien race ambushes the crew in an attempt to steal a time-accelerating device.