A college student is stabbed to death while working the nightshift at a convenience store, and her murder goes unsolved for 10 years until an informant steps forward.
Washington authorities are stunned when a mother of three dies from cyanide poisoning, and their murder investigation uncovers a pattern of tampering with boxes and blister packs.
After the mutilated body of 17-year-old Shauna Card is discovered on the bathroom floor in her Orlando, Fla., home, it will take years for investigators to finally crack the case.
When a 20-year-old woman is gunned down in a Maryland suburb, the case goes cold with few leads and almost no evidence, and it will take 25 years before investigators finally close in on the killer.
After recording her first album, country singer Melissa Haferman is murdered and her body is dumped in a vacant lot near a bus depot in Louisville, Ky.
In Kilgore, Texas, the residents are reeling from the execution-style slaying of five people abducted from a fast-food restaurant, and it will take several decades before the perpetrators are brought to justice.
A TV celebrity leads a major media campaign after a hardworking single mother is murdered in a Michigan town where violent crimes are nearly four times the national average.
Police from three different states join the hunt for a serial rapist and murderer, known as the I-5 Killer, who is terrorizing communities along Interstate 5 on the West Coast.
The rape and murder of a 19-year-old journalism student in her bed is the latest in a string of unsolved homicides in a college town.
During a slumber party, a man appears at 12-year-old Polly Klaas's bedroom door and abducts her at knife point.
Three blood-soaked dogs are the only witnesses to the brutal murder of Cathy Lamb in her Palm Beach, Fla., home, leaving detectives baffled by the gruesome crime scene.
Single mother Donna Kitowski heads to a Las Vegas supermarket late at night but never returns home, and soon the local TV news is reporting on a woman's near-lifeless body found in the desert..
Investigators must determine the identity of a murder victim whose skull was found on a highway in Florida.
Recounting a case surrounding the disappearance of a glamorous flight attendant. A lack of clues left detectives baffled, until a graveside discovery forced them to take a second look at some familiar faces
Tuesday 21st April 5:00pm EDT - Investigation Discovery
The case of Kathleen Smith, who was bludgeoned to death and set on fire in her Arizona home in October 1984. Detectives had two suspects, but no hard evidence to tie either of them to the attack. Fifteen years after the 20-year-old's murder, a tip-off from a notorious killer reopened the investigation
The case of 33-year-old Bob Henry, who was shot dead in broad daylight outside the Tacoma, Washington warehouse where he worked in September 1995. The execution-style murder looked like a professional hit, and the investigators' first quest was finding the weapon used
The murders of John and Nancy Bosco, shot at close range in their Montana home in August 1993. With few clues, the investigation to find the assassin soon stalled so John's mother eventually turned to an unorthodox source for help
A pillar of the Haitian community in Spring Valley, New York, is gunned down in his driveway, and the suspects include the victim's wealthy yet terminally ill second wife, his alleged mistress, and her gun-toting ex-husband
The case of 18-year-old Amy Roman, who was murdered in her Boston apartment in May 1990. Though police believed the young mother knew her assailant, the trail went cold, prompting her relatives into launching an investigation of their own. Fifteen years later, an arrest was made
Tuesday 21st April 4:00pm EDT - Investigation Discovery
The discovery of several women's bodies alongside the road near Tampa, Florida, prompting detectives to fear a serial killer was on the loose
Babysitter Karen Slattery is brutally stabbed and raped while babysitting in Southern Florida's Delray Beach. Case cold until a similar crimes terrorises in nearby Boca Raton.
The murders of Mike MacIvor and his heavily pregnant wife Missy, who were strangled to death in their Florida Keys home in August 1991. Suspicions about drug smuggling and a tip about a business deal gone wrong directed detectives to Belize, but for a while the case made little progress. However, investigators later took a new approach that led them straight to the killer
Documentary revealing the untold stories of how investigators caught notorious murderers. The first case is that of violinist Helen Hagnes, whose body was discovered at New York's Metropolitan Opera House in 1980
A body is discovered in an apartment fire; police catch the killer with blood found in the kitchen.
A nurse vanishes from her house and only her car is found.
Mother and grandmother, Edna Walton, is found dead in her home.
A dairy farmer and his wife are found dead in the living room of their home.
Children playing on the shore of a river find body parts in a bag.
A woman is certain that her husband was wrongly convicted of killing her mother and starts an investigation of her own.
A woman vanishes on her way to the airport; her body is found two weeks later in the trunk of her car.
A woman shows her home to a killer pretending to be a buyer.
Detectives discuss their hunt for a murderer, rapist and master of disguises, who dressed up in ladies' clothes in order to get into women's homes.
The murder of 29-year-old Renee Rondeau, who was found strangled in the bathroom of her Lakeview apartment the day after Halloween in 1994. Three years later, Andre Griggs and Benita Johnson were convicted of the crime
Detectives reveal how DNA evidence led them to 15-year-old Nanine Grimes' killer, a quarter of a century after she was stabbed more than 80 times in her Adams County home in September 1980
Detectives investigate the murder of two women in Minnesota. The evidence points to a serial killer, but they wonder whether the deaths are linked or just a sinister coincidence
Detectives hunt for the murderer of a 30-year-old mother. However, even when they think they've found their killer, they face a frustrating search for evidence.
Using a novel technique involving a deck of cards, detectives crack a 32-year-old cold case, finally bringing an assassin to justice.
Examining the case of Nancy Manni, whose body was found in Chesapeake Bay, which straddles the US states of Maryland and Virginia, in 1993. Four years later her case appeared on a TV crime series with the police no nearer to tracking her killer
Barbara Lloyd is stabbed to death in her home while her children are sleeping
Investigators reveal how they unravelled a business manager's endless string of lies in order to discover who had the means and motive to shoot him dead.
Investigators reveal untold stories of how they caught notorious murderers, beginning with the struggle to trace the killer of a 42-year-old woman.
A retired real estate agent is bludgeoned to death in his garage and detectives suspect foul play.
An unlikely witness, a dog tag, and some unusual bruises lead police to the killer of a man pummeled to death in a pub.
A Vancouver man is shot on his doorstep; other local murders appear to be connected.
A cab driver is murdered, mutilated, and dumped in a parking lot; days later another body sends police looking into 'the case of a lifetime.'
While digging in a dumpster, a homeless man makes the gruesome discovery of a human arm; after a second arm is found at the scene, the hunt is on for a killer - and the rest of the body.
An active senior disappears and a strange man is found at his home claiming to be there to check on the plants.
A mother leaves for a weekend and is never seen again; a detective goes undercover to find the killer.
A young woman goes for a ride and her body is found by a river; two more assaults and a fatal mistake lead to the killer.
While searching for a missing realtor and his wife, police make a grisly discovery inside the trunk of a car - their bodies; a nationwide hunt for the killer ensues.
The murder of two taxi drivers over a two day period stuns the city of Austin, Texas; many years later a critical piece of evidence cracks the case.
A well-liked teenager is found dead at a nearby school, but the case goes cold; years later a stabbing hundreds of miles away finally cracks the case.
A body found in a cement quarry has the signs of a mob hit, but as detectives look into the case, they discover a far stranger truth.
When a woman's two husbands die of the same illness, investigators suspect the wife may be a coldblooded killer.
A man's body is found near train tracks and his girlfriend is missing; while searching for the killer and the missing girl, investigators land in the world of freight train riders and serial killers.
An Orange County woman is shot in broad daylight; the case goes cold until a similar shooting takes place and a startling link is revealed.
A woman and her sons are rushed to the hospital complaining of extreme pain and nausea and test positive for a rare and deadly poison.