Mannix sets out to help a detective friend (Claude Akins) who has been charged with murdering a notorious loan shark.
En route to a fishing trip, Mannix can't seem to escape danger when he stumbles across the headquarters of a murder-for-hire ring.
A hunt for a lost plane and pilot leads Mannix to defend his life in a mountain ghost town; guests Jeanette Nolan, Charles Dierkop.
Street gang members plan to kill Mannix in a show of force to intimidate a rival gang that is threatening their territory.
A deranged girl (Dawn Lyn) who saw her father's murder thinks she killed him; guests Beverly Garland, Pernell Roberts, Sam Elliott.
An escaped convict (Greg Morris) saves Mannix's life after the detective's plane crashes in the wilderness; guest Edward Winter.
Mannix searches for an old friend's missing son, who is hated in his town after being convicted of rape and murder; guest Anthony Geary.
A clairvoyant foresees an attempt to kill a woman (Joan Van Ark) Mannix has been hired to protect; guest Robert Brown.
A blackmailer threatens to expose the unsavory past of a politician's wife (Jessica Walter); guests John Gavin, Milt Kamen.
The daughter (Anne Archer) of a businessman imprisoned for stealing a payroll hires Mannix to investigate her father's mysterious death.
A hobo (David Wayne) becomes the target of gunmen every time he puts on his patchwork coat; guests Lloyd Bochner, Barbara Babcock.
A prospective candidate (William Shatner) asks Mannix to find anything his political enemies could use against him; guest Susan Flannery.
A socialite (Susan Strasberg) asks Mannix to prove her guilty of a murder for which her brother has confessed; guest Tina Louise.
The investigation of his former girlfriend's death leads Mannix to a tycoon (Jason Evers) and a woman pilot; guest Joanna Miles.
Peggy poses as a prostitute to help police crack a narcotics ring; guest Joyce Van Patten.
Elderly sisters (Elsa Lanchester, Ruth McDevitt) foil a gangster's plan for a perfect murder; guests Dana Elcar, Abe Vigoda.
A mysterious enemy who has marked Mannix for death taunts the detective and kidnaps Peggy; guest Clu Gulager.
A businessman finds his wife murdered, his best friend fleeing the scene and a cache of jewels missing; guest Meg Foster.
Mannix puts his investigative expertise to work when a wealthy woman is charged with the murder of an international playboy.
Evidence in a murder Mannix is investigating points to Peggy's friend (Sandy Champion), a supposedly reformed juvenile delinquent.
Official records rule that a plant foreman's death was accidental, but Mannix is hired to prove otherwise.
A slain private detective's cases lead Mannix to blackmail, adultery, drugs and loan sharking; guests Adam West, Nehemiah Persoff.
Mannix poses as a crop-duster to look into the disappearance of two pilots employed by an embattled orange grower; guest Jeanette Nolan.
A deported mobster's (Harold Gould) foes think he has returned and try to find him; guests Belinda J. Montgomery, Christopher Connelly.
When he agrees to help a 12-year-old boy find his valuable stamp collection, Mannix doesn't realize that he's walking into a swindling case.
A soldier (Martin Sheen) thought killed in Vietnam surfaces with amnesia and a forged passport under a new name; guest Pamela Shoop.
Mannix becomes involved with a woman belonging to the New Orleans gang he infiltrated for the police; guests Robert Mandan, John Colicos.
An honored former Air Force pilot is killed just before he is to demonstrate an experimental plane for the press; guest Dabney Coleman.
It's not smooth sailing for Mannix when he sets out to investigate a society woman's disappearance from her husband's yacht.
An attempt is made on the life of an altruistic doctor (Joseph Campanella); guests Burgess Meredith, Fionnula Flanagan.
A man tries to kill the priest (Anthony Zerbe) who heard him confess to contracting his girlfriend's murder.
A bogus sheriff's helicopter rescues a prisoner (Rip Torn) Mannix was holding; guests Eddie Egan, John McLiam.
Head injuries from a race-car crash make Mannix hallucinate; guests Mariette Hartley, Elsa Lanchester.
Jewels worth $8 million need to be transported from London to the United States -- and Mannix is elected to do the job.
A police lieutenant (Steve Ihnat) is suspended for killing someone he had a grudge against; guest Leslie Parrish.
A nightclub singer (Lou Rawls) flees rather than face a minor traffic infraction; guest William Marshall.
Mannix refuses to believe the overwhelming evidence against a client accused of murdering his wife and sets out to prove the man's innocence.
A power struggle between two crime lords may erupt into war; guests Barry Sullivan, John Colicos.
The man Mannix suspects of attempted murder turns out to be fictitious; guests Charles Aidman, Jessica Walter, Art Buchwald.
Mannix's client secretly doesn't want him to solve the case; guests Jane Merrow, Madlyn Rhue, Jon Cypher, Jack Ging.
A computer designer is killed before he can submit plans for a computer to his employer; guest Paul Stevens.
Mannix learns a slain private investigator friend was working for a comic (Milton Berle) who won't discuss his blackmail case.
A condemned man insists he committed a murder even though the evidence indicates that he is innocent.
A private detective is murdered after learning more about a blackmailer than his employer wanted him to know; guest Vic Tayback.
A man hires Mannix to find his runaway daughter (Pippa Scott), then tries to pay the detective to cancel the search.
Mannix is hired to retrieve negatives of a retired general (Andrew Duggan) with a woman other than his wife.
A singer (Joanna Pettet) is kidnapped by hoodlums who think she knows the location of a hidden fortune.
Kidnappers will return Peggy if Mannix investigates a company not friendly to inquests; guest Georg Stanford Brown.
A police detective (Robert Foxworth) acts suspiciously after taking custody of a criminal Mannix captured; guest Stacy Keach Sr.
A Little League manager goes into hiding after a mobster makes an attempt on his life; guest J. Pat O'Malley.
Mannix uncovers a hidden identity when a woman hires him to rescue her alcoholic brother (Vic Morrow) from skid row.
A woman hires Mannix when Soviet agents try to recover a handwritten portion of "Das Kapital" she has inherited.
A factory worker dies during a labor dispute in Mannix's hometown; guests Victor Jory, Anthony Caruso.
Mannix is told a murder he recently witnessed happened a year before; guests Dean Stockwell, Shelley Fabares.
Mannix tries to unravel the reasons why a college professor's stepdaughter would be a candidate for kidnapping.
A couple (Rosemary Forsyth, Guy Stockwell) being blackmailed hires Mannix when it appears the wife, not the extortionist, may go to jail.
Mannix joins with the police to search for a compulsive killer who has just claimed his eighth victim.
Mannix probes the hit-and-run death of a woman who discovered her husband's (Jan Murray) dealings with the mob.
Believing her father's killer is still around, an heiress seeks Mannix's help in tracking down the murderer. Guest star: Diane Keaton.
A wheelchair-ridden former athlete (Carol Lynley) hires Mannix to investigate threatening telephone calls.
A man hires Mannix to find his college basketball player son; guests Lew Alcindor (Kareem Abdul-Jabbar), Gail Goodrich.
A reunion of Mannix's high-school football team in a ghost town results in murder; guests Jason Evers, Charles Aidman, Diana Muldaur.
A couple's argument reveals a long-hidden murder to their son; guests Rosemary DeCamp, Jacqueline Susann.
Believing her husband's current murder investigation threatens his life, a police lieutenant's wife hires Mannix.
A police chief (Robert Lansing) searches for an officer, a former convict, suspected of robbery and murder; guest Ruth Roman.
Amnesiac Mannix attempts to identify a woman's killers before they can reach him; guest J. Pat O'Malley,
Mannix and a widow (Susan Howard) search for the killer of her husband, a mystery man with unexplained riches.
A black marketer's widow (Katherine Justice) hires Mannix to learn why she is being followed.
A psychic has recurring dreams of Mannix's death after she sees his picture in the newspaper; guest Kim Hunter.
In a supposedly abandoned theater, gangsters map out murder plans -- but a 7-year-old girl overhears the plot.
Mannix is scheduled for execution after uncovering a supposedly dead anarchist's plot to take over the country.
Mannix stops for coffee in a cafe taken over by mobsters; with Pat Quinn, Barry Atwater.
Injured Peggy falls for a hospitalized African leader marked for death by foreign agents.
Mannix ties a Las Vegas comic to the disappearance of a gambler who had just lost $230,000 in the casino.
Mannix enlists a newsman's help when prisoners holding a guard hostage demand the detective clear a condemned man.
Mannix must find the antidote for a slow-acting poison administered to him by an espionage ring; guest Robert Ito.
After three attempts on his life, Mannix suspects he isn't the real target; guests Loretta Swit, Victor French.
A washed-up boxer (Brock Peters) is suspected of the murder of a gambler who fixed bouts; guest A Martinez.
A gangster's widow (Jo Van Fleet) hires Mannix, facing prison on theft and murder charges, as her bodyguard; guest James B. Sikking.
A member (Darren McGavin) of Mannix's old Army unit tells Mannix he killed two people to avenge a combat grievance.
A series of carnival accidents appear to be attempts on the owner's life; guests Michael Conrad, Gordon Jump.
A crime ring threatens to flood a town with nerve gas unless residents give them $1 million.
Twin sisters, one a prime suspect, don't want Mannix investigating a TV commentator's death.
Peggy and her son are held hostage for a roll of film in Mannix's possession that has already caused a death; guest Robert Pine.
While investigating a robbery-murder case, Mannix discovers that a mentally disturbed girl may be setting herself up for murder.
After three attempts on his life, Mannix learns the only possible suspect is already dead; guest Loretta Swit.
A woman (Jessica Walter) with a double identity hires Mannix, her husband's old Army buddy, to find who is trying to kill her.
Hired to locate a sailor in line for a large inheritance, Mannix learns he may be setting up the man's murder.
A married couple's incessant fighting turns to murder; guests Robert Lansing, Diane McBain, Mike Farrell.
When eyewitnesses identify the man who shot a pharmacist during a holdup, Mannix has a rough time trying to prove the man's innocence.
Mannix sets a trap for a blackmailer harassing a wealthy businessman, but winds up hunted by police.
Mannix discovers he needs a cryptology expert when he tries to clear the name of Peggy's late husband in a police payoff case.
The wife of a tough police detective hires Mannix to find her son, who she believes was involved in an armored-car robbery.
Mannix learns the strongest motives in a championship racehorse's theft belong to the animal's owners.
An aviation executive hires Mannix to learn who sabotaged his private jet; guests Susan Howard, Yvonne Craig.
Blinded in a shooting, Mannix must acclimate to his condition to find the would-be killer.
The search for a missing hit-and-run victim puts Mannix in the midst of a war between crime families.
Mannix struggles with a case in which a woman with a questionable memory believes she is a killer's target.
Although a man's drowning has been ruled accidental, his widow hands the task of a murder investigation to Mannix.
Mannix has some unexpected company when three escaped convicts decide to use his office as a hideout.
Mannix looks into a 2-year-old crime to clear a small-town doctor of malpractice charges; guests Lee Meriwether, Barbara Babcock.
An egotistic star (Robert Conrad) doesn't believe Mannix's contention that someone wants to kill him.
Mannix tries to mend severed ties with his estranged father. Guest: Vera Miles.
A police lieutenant (Robert Reed) slaps a murder charge on an attorney who claims he wasn't at the scene of the crime.
Wrongly accused of murder, Peggy's friends (Georg Stanford Brown, Geoffrey Deuel) flee rather than talk to police.
Mannix fears he accused the wrong man of the murder of a respected family's youngest son.
In Las Vegas, Mannix probes a case involving double identities, a missing body and $250,000 in cash; guest Sue Ane Langdon.
There's a mix of murder and political intrigue for Mannix when a newspaper publisher hires him to uncover the reasons for his daughter's (Sally Kellerman) strange behavior.
Mannix's secretary may walk out the door when he accuses her boyfriend (Robert Hooks) of stealing several cartons of morphine.
Mannix finds conflict and confusion searching for a missing contractor; guests Susan Oliver, Paul Winfield.
Mannix searches for stolen money and encounters the thieves, a girl, a British detective and a man who knows its location.
When Mannix rushes to rescue a kidnapped policeman, he discovers that the abductor plans to murder everyone -- including him.
Peggy's boyfriend (Yaphet Kotto) disappears; Mannix learns he is an escaped convict; guest Anthony Zerbe.
Mannix learns a deceased woman was the ex-girlfriend of his longtime foe (Lloyd Bochner); guest Nancy Kovak.
A businessman (William Windom) tries to kill Mannix, but won't tell who made him do it; guests Antoinette Bower, Philip Ahn.
A petty criminal's bizarre death may be connected to the gubernatorial campaign of Mannix's old rival; guest Slim Pickens.
A group of 21 people hires Mannix to prove a model's death wasn't suicide; guest Larry Linville.
Mannix visits a small mountain community to help out a friend in need and discovers he's the prime suspect in a murder case.
Being called to testify in a murder case against a man he once sent to jail makes Mannix suspicious; guest Dana Elcar.
Mannix thinks he witnessed a murder during a helicopter flight, but there's no body and no report of a crime.
An aviation tycoon's son awakens to find his hand injured, his girlfriend missing and his memory a blank; guest Frank Campanella.
Mannix looks for new evidence to free a man he helped wrongly convict of embezzlement; guests Cloris Leachman, Barbara Babcock.
A millionaire asks Mannix to find and return his estranged wife, even though she has been reported dead.
Kidnappers will kill a surgeon's (Fritz Weaver) son if the doctor does not allow a patient to die; guest Veronica Cartwright.
The pages of a missing manuscript may provide Mannix with some clues in the case of an unsolved death.
A petty criminal's death leads Mannix to an investigation that entangles him in a web of grand larceny and deceit.
An auto racer's wife (Jill Ireland) hires Mannix to investigate her husband's death on the track; guests Nicholas Colasanto, Jed Allan.
A Briton and a group of youths snatch a wounded boy who uttered a cryptic message to Mannix before passing out.
An airport security officer's wife (Sheree North) disappears; guests Gerald S. O'Loughlin, Lee Bergere.
A deaf girl who read the lips of a man plotting a crime helps Mannix find evidence that evaded police.
An art collector fears his new Renoir is a fake.
Mannix uncovers an unsolved homicide while protecting a controversial writer.
A decades-old labor dispute that culminated in a deadly bombing comes back to haunt Mannix.
A blackmailer lures Mannix into an investigation of purported miracles.
An international narcotics ring has marked Mannix for murder.
Mannix exposes a plot to conceal the true value of an underworld moll's necklace.
Feuding Wickersham and Mannix are captured on the waterfront.
Mannix and Wickersham feud over a case involving a laser ray and a dead agent.
Mannix tries to locate a homicidal maniac who may be killing police.
Mannix protects a flamboyant film star after a time-bombed press conference.
Mannix works undercover at a health ranch for alcoholics.
Mannix investigates the murder of an undercover policeman.
A newspaper publisher finds himself in the midst of a libel suit and dirty politics.
A blackmailer's victims won't tell Mannix why they're being victimized.
A mother's plea sends Mannix in pursuit of a desperate killer.
Mannix searches for a dead man in a cattle town.
A young socialite linked to murders hires Mannix to investigate her fiance.
Lew assigns Mannix to locate a delinquent coed.
A model hires Intertect to find her boyfriend, who threatened suicide.
A child convinces Mannix to prove her father innocent and prevent his execution.
Mannix woos a missing scientist's daughter, hoping to find him.
Mannix is framed for the murder of the man he's investigating.
Mannix investigates an industrialist who wants to run for governor.
Joe Mannix must find the kidnapped daughter of a Palm Springs mobster.