Student Natalee Holloway disappeared in Aruba while she was on holiday. Two years later, the team looks for new evidence that might reveal what really happened.
The Zodiac Killer claims the lives of five known victims while taunting the police and the press from December 1968 to October 1969 in California.
Police follow leads in the disappearance of 3-year-old British girl Madeleine McCann from a resort town in Portugal.
The team travels to Boulder, Colo., to investigate the unsolved murder of child beauty queen JonBenet Ramsey in 1996.
A construction worker in Kansas falsely claims he needs to report for jury duty, leaves his job early and is never seen alive again.
John, Carla and Patrick go to Ohio to search for clues in the disappearance of a 25-year-old man.
The team investigates the unsolved ax murders of two adults and six children while they slept in a house in Villisca, Iowa, in 1912.
The grisly murders of two girls in 1999 continue to haunt Dothan, Ala.
Psychic profiler Carla Baron, medium John J Oliver and paranormal investigator Patrick Burns investigate the murders of two girls who were last seen alive getting into a blue truck at a convenience store in Arizona.
Missing college student Kristen Modafferi's trail stops at the water's edge in Land's End Park in the San Francisco Bay Area.
Investigators in Washington, D.C., search for links between the murders of Joyce Chiang and Chandra Levy, who both interned for congressmen, frequented the same Starbucks in DuPont Circle, and whose bodies were found in parks.
A woman discovers a dead body on the beach.
Unconventional investigators try to uncover new clues in the cold case of Molly Bish, who was kidnapped from her lifeguard job in broad daylight.
A popular high school teacher vanishes.
After a young man is found dead by the side of a road, the case is classified as an accident, but things don't quite add up.
A brand new Mini Cooper and a damaged laptop are the only clues in the disappearance of a district attorney.
Investigators try to puzzle out what happened to a young woman who vanished after a celebratory dinner with her fiance and friends.
The team looks into the case of a University of Georgia Law School student who was found dead in her burned apartment and apparently knew her killer.
A psychic, a medium and a forensic expert team up to probe the unsolved murder of lesbian hikers along the Appalachian Trail.