Detectives search for an elderly woman who vanished after returning from a doctor's appointment, with the suspicion that the use of pain medication may have contributed to her disappearance.
A man reports that his missing girlfriend left him an ominous phone call; a Chicago teenager falls under the influence of a gang member considered to be armed and dangerous.
Police detectives investigate the subculture of Chicago's black gay males when a young man leaves a disturbing voice mail message and then goes missing.
A woman reports her husband missing the day after their second wedding anniversary; a missing hotel guest is spotted on surveillance video leaving the establishment.
An online predator may be behind the disappearance of an aspiring model; police race to locate a mentally disabled man before he becomes a victim of street violence.
Detectives probing a dental student's disappearance turn their focus on the victim's husband and mother, but the investigation stalls after both pass their polygraph tests.
A missing mother of four leaves behind a suicide note; a detective searches for a disoriented woman wandering the streets of Chicago.
Police suspect that one man may be responsible for the disappearances of two women and their young children.
A talented man vanishes on his bicycle; detectives must untangle the past to uncover the truth.
The children of an Iraqi immigrant worry she is trying to return to Baghdad; daughters fear their mother was a victim of foul play.
A 17-year-old teen and her child are missing; an elderly man vanishes en route to a Christmas party.
Detectives search for a 14-year-old girl who was snatched by an older teen with possible gang connections; an elderly man with serious neurological problems goes missing.
A missing man's life is under threat; a missing teenager has a rare sleep disorder.
Caretaker reports her 63-year-old cancer patient is missing; a missing mattress may solve the case.
A missing college sophomore is seen on video walking toward the waterfront; a woman threatens to jump off a bridge; a drug deal gone bad forces a gang member into hiding, endangering his family.