Furious because she feels that Thomas Bruhme II (Sidney Blackmer) caused her sister's suicide, Kay Kerrigan (Joan Bennett) shoots him after a confrontation. Now wanted for murder, she dyes her blonde hair dark and goes on the run, boarding a ship for Asia. She's followed there by Detective Sam Wye (Fredric March), an ace sleuth and notorious womanizer. He finally tracks her down, and the two fall in love. As other detectives close in, will Wye protect her identity or turn her in?