Sgt. Joe Friday (Jack Webb) is called back from vacation to investigate the disappearance of a group of young women. He reunites with his partner, officer Bill Gannon (Harry Morgan), and their investigation leads them to a social club for young people. From there, they learn that the last person the girls were with was a man named J. Johnson (Vic Perrin). Friday and Gannon discover that Johnson is actually a serial killer who poses as a photographer.